Genetic Aspects of Child and Adolescent Alcohol-Substance Use Problems
P: 1-15
March 2024

Genetic Aspects of Child and Adolescent Alcohol-Substance Use Problems

Turk J Child Adolesc Ment Health 2024;31(1):1-15
1. Uludağ Üniversitesi Tıp Fakültesi, Çocuk ve Ergen Ruh Sağlığı ve Hastalıkları Anabilim Dalı, Bursa, Türkiye
2. Özel Moodist Hastanesi, Çocuk ve Ergen Ruh Sağlığı Kliniği, İstanbul, Türkiye
3. Yedikule Surp Pırgiç Ermeni Hastanesi, .Çocuk ve Ergen Ruh Sağlığı Kliniği, İstanbul, Türkiye
4. Bakırköy Prof. Dr. Mazhar Osman Ruh Sağlığı ve Sinir Hastalıkları Eğitim ve Araştırma Hastanesi, Çocuk ve Ergen Ruh Sağlığı Kliniği, İstanbul, Türkiye
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Received Date: 16.01.2021
Accepted Date: 15.05.2021
Publish Date: 27.03.2024


Genetic effects in child-adolescent drug use dependence are generally affected by age, gender, specific drug and stage of use. The genetic effect in alcohol-drug use increases with increasing age and the stage of use. In children and adolescents, genetic studies are mostly are carried out within the framework of gene-environment interactions, because environmental effects are more evident. No genetic analysis method adequately explains the variance, so the explanation of the phenotypic variance by the genetic effect during adolescence is low. Genetic studies related to alcohol-drug use disorders in children and adolescents focused more on tobacco/nicotine, alcohol and cannabis. Dopaminergic (DRD2, DRD4), serotonergic (5-HTTLPR), GABAergic (GABRA2, SLC6A1; GABRA6), oxytocin, opioid (OPRM1) and nicotinic receptor systems (CHRNA5- CHRNA3-CHRNB4) have been studied more frequently. In adolescents, genes associated with drug metabolism may play a greater role for abuse and/or addiction, while subjective effects of drugs may be important for regular and/or intensive use and novelty seeking/risk taking in initiation. Adolescents with any family history and/or environmental risk factor along with any of the risk gene polymorphisms should be considered as a genetically high risk group

Keywords: Alcohol, substance, addiction, genetics, adolescence


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